Synergistic Impact of Vitamin D3 and PRF on Peri-Implant Outcomes in Dental Implant Placement: A 12-Month Randomized Controlled Trial.

European Journal of Prosthodontics and Restorative Dentistry (2026) 34(2),163–172

Platelet rich fibrin-Vitamin D3-Implant – ISQ- Osseointegration.

1. Anes Adnan Alshamaa* (Corresponding
Author)
BDS, MSc, College of Dentistry,
University of Al-Maarif, Anbar, Iraq
Email:Anes.adnan@uoa.edu.iq
Phone: +9647802227325
ORCID: 0000-0002-3847-1444
2. Hani M. Al-Kufi
BDS,MSc, College of Dentistry, The
Islamic University, Najaf, Iraq
Email:hani.alkufi@iunajaf.edu.iq
Phone:+9647810885225
ORCID:0000-0001-7615-5453
3. Abdulkhaleq Mohammed Qaraghuli
BDS,MSc, PhD researcher, Department of
Medical Biotechnologies, Division of
Fixed Prosthodontics, UniversityofSiena,
Siena, Italy.
Email:dr.abdulkhaleq91@gmail.com
Phone: +964 770 433 3814
ORCID:0009-0003-7755-9769
4. Hanan Elsayed
BSC, MSc, PhD biostatistics and
bioinformatics, Ministry of Health and
populations. Egypt

mri.hanan.m.informatics18@alexu.ed
u.eg
ORCID:0000-0001-6978-8770

Synergistic Impact of Vitamin
D3 and PRF on Peri-Implant
Outcomes in Dental Implant
Placement:A 12-Month
Randomized Controlled Trial.

Objective: The purpose of the paper was to study the influence Background/Purpose:A biological process known as osseointegration,in which a direct structural and functional connection is formed between the dental implant's surface and living bone,is essential to the success of dental implants.This randomized controlled trial assessed the immediate dentalimplant success rates of vitamin D3 alone versus vitamin D3 plus platelet-rich fibrin (PRF),by comparing both interventions to routine implant placementwithout adjunctive therapy. MaterialsandMethods:The study included a total of 45 randomly assigned patients who received immediate implants placement to one of three groups: Group 1(PRF+vitamin D3), Group 2 (vitamin D3 only), or Group 3 (control).Radiographic bone density, soft tissue health (bleeding index, probing depth),and implant stability (ISQ) were evaluated at baseline, three, six, and twelvemonths. The Kruskal-Wallis test (p<0.05) was used for the statistical analysis. Results: The PRF+vitamin D3 group had mean differences of 8–12 ISQ units compared to controls by 12 months, and their ISQ values were considerably higher than those of the other two groups at all intervals(p<0.01).Additionally, this group showed better probing depths and lower bleeding ratings compared to control. In every metric, the controls performed the worst, whilethe vitamin D3-only group improved in a Moderate level. Conclusion: In comparison to mono therapies or conventional procedures, the synergistic combination of PRF and vitamin D3 significantly enhanced peri-implant tissue health, osseointegration, and rapid implant stability. Theseresults provide support to the regular clinical application of this combinedstrategy to maximize rapid implant results. Future research should focus on cost-effectiveness and long-term (>5 years) survival rates. Keywords:Platele rich fibrin-VitaminD3-Implant–ISQ-Osseointegration.

Received: 21.04 2026 Revised: 30.04.2026 Accepted:09.05.2026

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