Optimization of Therapeutic and Preventive Measures for Periodontal Diseases in Pregnant Women with Iron Deficiency Anemia: A Prospective Comparative Clinical Trial

Iron deficiency anemia, pregnancy, periodontal disease, salivary biomarkers, multidisciplinary therapy, maternal health

1Sadikova Shoira Amriddinovna
Assistant, Department of Therapeutic
Dentistry Samarkand State Medical University
Samarkand, Uzbekistan
e-mail: shoira.sadikova.1992@mail.ru,
ORCID: https://orcid.org/0009-00041694-0600

2Baxramova Farangiz Nuriddin qizi
Head of the Department of Dentistry
Alfraganus University
Tashkent, Uzbekistan
e-mail: fbakhramova1996@gmail.com
ORCID: https://orcid.org/0009-0007-2092-5333

3Absalamova Nigora Fakhriddinovna
PhD, Associate Professor, Associate
Professor of the Department of Dentistry,
Alfraganus University, Tashkent, Uzbekistan
e-mail: Arogin_stomatolog@mail.ru
ORCID: https://orcid.org/0009-0006-2656-1465

4Abdukadirova Nargiza Baxodir qizi
Department of Dentistry, Alfraganus
University, Tashkent, Uzbekistan
e-mail: nbabdukadirova94@gmail.com
ORCID: https://orcid.org/0000-00027431-5801

5Sevara Mirgulyamovna Rizaeva
Doctor of Medical Sciences (DSc),
Professor, Department of Faculty
Orthopedic Dentistry, Tashkent State
Medical University, Tashkent, Uzbekistan,
e-mail: rizaeva_sevara@mail.ru
ORCID: https://orcid.org/0000-00017864-5624

6Alikulov Erkin Azamovich
Candidate of Medical Sciences, Head of
the Department of Clinical Sciences,
Gulistan State University, Gulistan,
Republic of Uzbekistan
e-mail: aliquloverkin267@gmail.com
ORCID: https://orcid.org/0009-00096

Received-13-05-2026
Revised-15-06-2026
Accepted-20-06-2026

European Journal of Prosthodontics and Restorative Dentistry (2026) 34 (04s), 522-530

Optimization of Therapeutic and Preventive Measures for Periodontal Diseases in Pregnant Women with Iron Deficiency Anemia: A Prospective Comparative Clinical Trial

Periodontal disease during pregnancy, particularly when complicated by iron deficiency anemia (IDA), represents a significant public health challenge requiring comprehensive management strategies. This prospective comparative clinical trial evaluated an integrated multidisciplinary treatment algorithm addressing both systemic and local pathogenic factors. Two hundred seventy-four pregnant women with confirmed IDA and periodontal pathology were distributed into control (n=150) and intervention (n=124) groups. The intervention cohort received combined therapy including Ferlatum Fol, Sensodyne Pronamel, Phosphalugel, Gum Hydral Rinse, and digital monitoring via the IDA-PP mobile application. Primary outcomes included periodontal status assessed using PMA and CPITN indices, salivary biomarkers (calcium, protein), and systemic hemoglobin levels. Results demonstrated significant superiority of the integrated approach: intervention group achieved 41.4% reduction in PMA index (27.5% to 20.5%, p<0.001), 2.7-fold reduction in affected sextants (0.72 vs. 1.94, p<0.001), and restored salivary calcium to 2.040 mmol/L (22.8% superior to controls, p<0.001). Direct correlation between hemoglobin normalization and salivary protein restoration (r=0.78, p<0.01) established systemic metabolic correction as essential for oral health preservation. Conclusions: Integrated multidisciplinary management substantially outperforms conventional approaches, warranting adoption into standard clinical protocols for high-risk pregnant populations.

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