Therapeutic Advances in Oral Lichen Planus: A Scoping Review of Emerging and Precision-Based Treatment Strategies

Oral lichen planus; photobiomodulation; platelet-rich plasma; precision medicine; Janus kinase inhibitors.

Kiranbala Jena, MDS*1,
MDS, Postgraduate Trainee, Department of
Public Health Dentistry, Kalinga Institute of
Dental Sciences (KIDS), Kalinga Institute of
Industrial Technology (KIIT) Deemed to be
University, Bhubaneswar–751024, Odisha, India.
kironmayeejena@gmail.com
ORCID: 0009-0001-3721-3128

Ipseeta Menon, MDS, PhD2,
MDS, PhD, Professor, Department of
Public Health Dentistry, Kalinga Institute of
Dental Sciences (KIDS), Kalinga Institute of
Industrial Technology (KIIT) Deemed to be
University, Bhubaneswar–751024, Odisha, India.
ipseetam@gmail.com
ORCID:0000-0003-0112-8666

Gunjan Kumar, MDS, PhD3,
MDS, PhD, Professor and Head,
Department of Public Health Dentistry,
Kalinga Institute of Dental Sciences (KIDS),
Kalinga Institute of Industrial Technology
(KIIT), Deemed to be University,
Bhubaneswar–751024, Odisha, India.
drgk1014@gmail.com
ORCID: 0000-0002-8663-8472

*Corresponding author: Dr. Ipseeta Menon
* MDS, PhD, Professor, Department of
Public Health Dentistry, Kalinga Institute of
Dental Sciences (KIDS), Kalinga Institute of
Industrial Technology (KIIT) Deemed to be
University, Bhubaneswar–751024, Odisha,India.
ipseetam@gmail.com
ORCID:0000-0003-0112-8666

Received-15-06-2026
Revised-17-07-2026
Accepted-20-07-20.26

European Journal of Prosthodontics and Restorative Dentistry (2026) 34(5s),79-88

Therapeutic Advances in Oral Lichen Planus: A Scoping Review of Emerging and Precision-Based Treatment Strategies

Background: Oral lichen planus (OLP) is an inflammatory condition caused by the immune system that affects quality of life and has the potential for malignant transformation. Topical corticosteroids are the first-line treatment; however, recurrence and side effects have limited their long-term efficacy, leading to an increased demand for targeted and regenerative therapies. Objective: The aim of this review is to outline the currently available evidence on both conventional and novel strategies for OLP management and to review their clinical outcomes. Methods: This scoping review was conducted according to the Joanna Briggs Institute (JBI) methodology and the PRISMA-ScR guidelines. PubMed, Scopus, and Web of Science were searched for eligible studies evaluating OLP therapies. Data were categorized according to treatment modality and narratively synthesized. Results: A total of 35 studies comprising different therapeutic modalities were included. These studies demonstrated significant improvements in pain, lesion management, mucosal healing, and patient-reported outcomes. However, direct comparisons were hindered by significant variations in trial design, treatment protocols, outcome measures, and follow-up duration. Conclusion: Precision-based and regenerative therapies are becoming increasingly prevalent in the management of OLP. However, long-term followup studies and additional clinical trials are needed to determine their effectiveness and safety.

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