Effect of a Polyherbal Formulation of Cuminum cyminum, Murraya koenigii, and Trigonella foenum-graecum on Glycemic Control and Metabolic Health in Prediabetic Adults: An Experimental Study

Cuminum cyminum; Murraya koenigii; Trigonella foenum-graecum; polyherbal formulation; prediabetes; glycemic regulation.

Sahiba Saifi1, Assistant professor Galgotias
university, sahiba@galgotiasuniversity.edu.in,
orchid id – 0000-0001-9283-4958

Corresponding- Authors
Shahiduz Zafar2,
Professor Galgotias university,
Shahiduz.zafar@galgotiasuniversity.edu.in,
orchid id – 0000-0003-2764-7755

Md Nasar Mallick3,
Professor Galgotias university,
nasar.mallick@galgotiasuniversity.edu.in
orchid id – 0000-0002-5783-9814

Awaneet Kaur4,
Associate professor, Galgotias university,
awaneet.kaur@galgotiasuniversity.edu.in
Orchid id – 0000-0002-9310-8859

Received:25-06-2026
Revised:28-07-2026
Accepted:05-08-2026

European Journal of Prosthodontics and Restorative Dentistry (2026) 34(7s), 771-778

Effect of a Polyherbal Formulation of Cuminum cyminum, Murraya koenigii, and Trigonella foenumgraecum on Glycemic Control and Metabolic Health in Prediabetic Adults: An Experimental Study

Prediabetes is a high-risk metabolic condition that frequently progresses to type 2 diabetes and requires effective early interventions to improve glycemic regulation and metabolic health. This study aimed to prepare and evaluate a standardized polyherbal blend of Cuminum cyminum, Murraya koenigii, and Trigonella foenum-graecum through laboratory, preclinical, and clinical investigations. An experimental translational study was conducted involving standardized extraction, formulation, phytochemical screening, preclinical evaluation in streptozotocin-induced diabetic rats, and clinical evaluation in 60 adults with prediabetes. Participants received either the polyherbal blend combined with exercise or an exercise comparator. Hydroalcoholic Soxhlet extraction produced the highest extraction yields and a phytochemically rich formulation. In the preclinical phase, the polyherbal blend significantly reduced fasting blood glucose and improved antioxidant and biochemical markers. In the clinical phase, participants receiving the polyherbal formulation demonstrated greater improvements in Blood pressure, waist circumference, body weight, body mass index, fasting blood glucose, postprandial blood glucose, HbA1c, lipid profile and liver function biomarkers than those receiving the comparator intervention. The formulation was well tolerated, with only mild adverse events reported. Overall, the findings indicate that the standardized polyherbal blend possesses promising antihyperglycemic and metabolic benefits and may serve as a complementary method for enhancing glycemic regulation and metabolic health in adults with prediabetes. To validate its long-term efficacy and safety, more extensive randomised controlled trials with longer followup are needed.

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