Innovations in Dental Biomaterials for Periodontal Regeneration and Restorative Applications

periodontal regeneration, dental biomaterials, restorative dentistry, smart biomaterials, tissue engineering

1*Vjona Zekolli
Dentist, Department of Faculty of Medicine
Specialization: Dentistry
University of Prishtina “Hasan Prishtina",Prishtina
ORCID ID- 0009-0002-6273-5814
vjona.zekolli@hotmail.com

2Dr Vineet Gupta
Consultant Endodontist, MDS (Conservative
Dentistry & Endodontics), Faculty of Dental
Sciences,King George’s Medical University,
Lucknow, Uttar Pradesh.
Email ID:vineethegupta@gmail.com
ORCID ID: https://orcid.org/0009-0000-73824594?lang=en

3Dr. Mitulkumar Kantilal Bhut
Associate Professor, Department of Dentistry,
SMIMER Medical College Surat, Veer Narmad
South Gujarat University. ORCID ID - 00000002-4437-4114
Email ID: drmitulbhut22@gmail.com

4Dr Aishwarya M U
Lecturer, Department of Oral and Maxillofacial Surgery,
Nitte (Deemed to be University), AB Shetty
Memorial Institute of Dental Sciences
(ABSMIDS), Mangalore, India, 575018.
Email ID: draishwarya.mu@nitte.edu.in
ORCID ID: 0000-0002-7080-9484

5Dr. Mohammad Jalaluddin
Professor and Head.
Department of Periodontics and Implantology,
Kalinga Institute of Dental Sciences, KIIT
DEEMED UNIVERSITY, Bhubaneswar.
Email ID: drjalal1979@gmail.com
ORCID ID: 0000-0003-0090-8740

Received:26-06-2026
Revised:30-07-2026
Accepted:08-08-2026

European Journal of Prosthodontics and Restorative Dentistry (2026) 34(7s) 804–814

Innovations in Dental Biomaterials for Periodontal Regeneration and Restorative Applications

It is in the field of periodontal restoration and restorative dentistry that dental biomaterials have become the focal point of discussion because it is now possible to consider something beyond passive restoration in the current approaches, which facilitate the enhancement of biologically directed healing and functional restoration. This review synthesizes current evidence on the biological basis of periodontal regeneration, the classification of natural and synthetic biomaterials, and recent innovations in advanced regenerative systems. Particular attention is given to guided tissue regeneration membranes, hydrogels, injectable matrices, nanomaterials, bioactive ceramics, smart polymers, and restorative biomaterials with remineralizing, antimicrobial, and regenerative potential. The review also examines the expanding role of bioprinting, digital dentistry, and controlled drug delivery in improving the precision and personalization of treatment. Although these developments have substantially enhanced the therapeutic potential of modern dentistry, important barriers remain, including challenges related to biocompatibility, long-term clinical predictability, regulatory approval, economic feasibility, and translational validation. Current evidence indicates that advanced biomaterials can improve tissue healing, restoration longevity, and regenerative outcomes when appropriately designed and clinically applied. It is hoped that future advancements will be based on the creation of multifunctional, patient-specific systems, which combine regenerative, bioactive, and intelligent capabilities. In general, dental biomaterials have emerged as a very dynamic area of research with great potential to transform periodontal and restorative treatment with more predictable, less invasive and biologically integrated treatments.

•••••••••••••••••••••••••••••••• ejprd.org - Published by Riset Publication Services LLC

EJPRD

Copyright ©2026 by Riset Publication Services LLC